Founded in 2000 by Julian and Felix Baker, Baker Bros. Advisors is a private hedge fund based out of New York City. The two brothers are still at the helm of the fund, and along with around 25 employees, cater to 2 clients, notes Nikolaos Sismanis, a specialist in hedge funds and a contributing editor to Sure Dividend.

Together, they have combined their individual expertise to generate superior returns by focusing solely on the biotech industry. The fund has grown rapidly over the years due to its extraordinary returns and currently boasts approximately $17.6 billion of assets under management (AUM).

The Baker brothers have built a truly special hedge fund. Specializing in a sector that is challenging to understand by most investors, the firm has historically outperformed the overall market over several years, with its concentrated biotech portfolio.

Finally, the two brothers don’t believe in diversifying the fund’s portfolio. Instead, they emphasize that focusing on specific companies, which they can analyze and understand deeply and place concentrated positions in their securities, can generate superior returns over the long term. The top 10 holdings account for 75.7% of the total capital invested, confirming their inclination towards high-conviction investments.

Investors following the company’s 13F filings over the last 3 years (from mid-August 2019 through mid-August 2022) would have generated annualized total returns of 0.2%. For comparison, the S&P 500 ETF (SPY) generated annualized total returns of 13.3% over the same time period.

Performance over the past three years has lagged, but it could be a temporary phase for the fund, which, after all, focuses on long-term returns. Investors that are familiar with biotech companies are likely to find some hidden gems amongst their holdings.

Incyte Corporation (INCY)

Incyte Corporation focuses on the discovery, development, and commercialization of various therapeutics. Its flagship products include JAKAFI, which is a drug for the treatment of myelofibrosis and polycythemia, and Iclusig, a kinase inhibitor to treat chronic myeloid leukemia.

Unlike many biotech companies, which are pre-revenue, Incyte has been growing its top and bottom line for years. Revenues have expanded from around $169 million in 2010 to $3.32 billion over the past four quarters. The stock is trading at a forward P/E ratio of ~25, which is a near-record low valuation multiple for the company.

EPS over the medium-term is expected to grow by around 30% since Incyte is an industry leader, having essentially monopolized its areas of treatment. In that regard, the valuation seems compressed. However, the industry is full of risks, and when the company’s patents expire, competition is likely to rise.

The fund owns around 16.3% of the company, with a market cap of $15.9 billion. The position was boosted by less than 1% in the previous quarter.

BeiGene, Ltd. (BGNE)

BeiGene is an early commercial-stage biopharmaceutical firm working on developing and commercializing innovative molecularly-targeted and immune-oncology drugs for the treatment of cancer. It is the fund’s second-largest holding, occupying 21.3% of its total portfolio.

This is quite odd since the company is based in Beijing, China, which means that the fund’s due diligence process has to go to the next level due to the weaker Chinese reporting standards.

Despite the uncertainty surrounding BeiGene, the company has developed into a fully integrated global biotechnology company with operations in China, the United States, Europe, and Australia. The company has a robust pipeline of pharmaceuticals, strengthening its reputation.

Nonetheless, BeiGene produces miniature revenues against its $17.4 billion market cap, indicating that investors are betting heavily on the company’s long-term prospects. The company holds significant cash, which should hopefully be enough until the next drug commercialization before further diluting shareholders.

Baker Bros. held its position steady last quarter, though the fund still owns nearly 11.3% of the company.

BioMarin Pharmaceutical Inc. (BMRN)

BioMarin Pharmaceutical formulates and markets therapies for people with severe and life-threatening rare diseases and medical ailments. While the company’s revenue growth has seemingly stagnated over the past couple of years, it appears that the company’s development pipeline remains rather strong. Most recently, BioMarine got a positive CHMP opinion in Europe for ValRox for the treatment of Hemophilia type A.

BioMarin has had a place in Baker Bros’ portfolio since Q2 2012. The position was left unchanged during the previous quarter. BioMarin is now Baker Bros’ fourth largest holding, with the fund owning 4.11% of the company’s outstanding shares.

ACADIA Pharmaceuticals Inc. (ACAD)

ACADIA Pharmaceuticals focuses on the development and commercialization of small molecule drugs aimed at unmet medical needs in central nervous system disorders. The company features extraordinary revenue growth, at a 5-year CAGR of 34.6%. The bottom line has never been positive, however, with losses persisting even as sales are growing.

In March of 2021, Acadia had announced deficiencies identified by the FDA regarding its marketing application for Pimavanserin in hallucinations and delusions associated with dementia-related psychosis. Shares plunged by a massive 45%, and they have yet to recover since then. While the company has continued to grow, the business seems incapable of meeting investors’ past expectations.

This is one of the fund’s highest conviction picks, as Baker Bros still owns nearly 26% of the company’s shares, which have been held since 2010. While the fund has made great gains since, the recent plunge has definitely compressed its unrealized gains, as the position was held stable once again.

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