Anavex: Hope in Treating Alzheimer's

12/13/2017 5:00 am EST

Focus: HEALTHCARE

Tom Bishop

Founder, BI Research

Anavex (AVXL) is a biopharmaceutical company dedicated to the development of novel drug candidates to treat central nervous system diseases, notes small cap expert Tom Bishop, editor of BI Research.

Its lead candidate, Anavex 2-73 (A2-73) is currently in a Phase 2a clinical trial. A2-73 is an orally available drug candidate that targets sigma-1 and muscarinic receptors (rather than amyloid plaques).

The drug has a clean safety profile that shows promise to halt and/or possibly even reverse the course of Alzheimer’s. On 11/4, the company made a presentation at the 2017 Clinical Trials on Alzheimer Disease (CTAD) meeting.

This time the company had results through 2 years. A2-73 continued to show favorable safety and tolerability through 109 weeks.

Best of all the drug continued to work through 2 years on this cohort. Existing medication only slowed the decline for 6 months before the disease resumed its usual decline.


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A2-73 is also in preclinical testing on Parkinson’s (results should be forthcoming soon) with complete funding from the Michael J. Fox Foundation. And Biogen is doing bench testing on A2-73 for multiple sclerosis.

A2-73 has also shown promising preclinical results for the treatment of epilepsy, Rett Syndrome (a clinical trial may start fairly soon with funding secured recently from the Rett Syndrome Foundation), and infantile spasms (both of which have received orphan drug designation). 

All of the above at some point will make Anavex a tasty acquisition treat, if things continue to progress well. Nonetheless, the stock seems to be oblivious to all this news and is just marking time around $4 a share, perhaps impacted by yearend tax loss selling. I continue to rate the stock a buy.

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